Dicer Dependent MicroRNAs Regulate Gene Expression and Functions in Human Endothelial Cells

By Y. Suárez, C. Fernández‐Hernando, J. Pober, W. Sessa. Circulation Research, 2007

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The Role of MicroRNAs in Human Diseases (2010, background): “Similar observations were reported (57) for the anti-angiogenic function of miR-221 miR-222 in endothelial cells.”
Role of microRNAs in vascular diseases, inflammation, and angiogenesis. (2008, background): “Surprisingly, critical regulators of angiogenesis such as vascular endothelial growth factor (VEGF) and its receptor Flt1 were upregulated after Dicer depletion.(26,27) The VEGF-R2 (KDR) was upregulated in one study(26) but was not affected in another study,(27) which might suggest that this regulat”
An Endothelial-specific microRNA Governs Vascular Integrity and Angiogenesis (2008, background): “miRNAs have been implicated in regulating EC gene expression and function in vitro (Kuehbacher et al., 2007; Suarez et al., 2007), but the functions of miRNAs in EC biology in vivo have not been explored.”
MicroRNAs in development and disease. (2011, background): “This was confirmed by the knockdown of Dicer in human umbilical vascular endothelial cells (HUVEC), which exhibited defective proliferation, migration, and tubulogenesis (321, 584).”