Structure and function of the type 1 insulin-like growth factor receptor

By T. Adams, V. Epa, Thomas P. J. Garrett, Colin W. Ward. Cellular and Molecular Life Sciences (CMLS), 2000

621 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain (2016, background): “IR is related to the type 1 insulin-like growth factor receptor (IGF-1R); their ectodomains have 57% sequence identity and each binds insulin and the insulin-like growth factors IGF-I and IGF-II, though with varying affinity (Adams et al., 2000).”
Growth hormone, insulin-like growth factors, and the skeleton. (2008, background): “The cellular actions of IGF-I are mediated by the IGF-I receptor (IGF-IR), a receptor tyrosine kinase that is expressed in IGF target tissues (55).”
Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies. (2010, background): “IGF1 is best known for being produced by the liver in response to growth hormone stimulation and is essential for normal fetal and postnatal growth and development (Adams et al., 2000).”
An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors. (2003, background): “The order of disulfide-bonded modules in this domain is C2-C1-C1-C2-C1-C1-C2, as marked beside the domain.”