3-(aminomethyl)piperazine-2,5-dione as a novel NMDA glycine site inhibitor from the chemical universe database GDB.

By Kong T. Nguyen, E. Luethi, S. Syed, S. Urwyler, Sonia Bertrand, Daniel Bertrand, Jean-Louis Reymond. 2009

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The enumeration of chemical space (2012, background): “We have reported ligand discovery examples for inhibitors of the NMDA glycine site, 138 , 139 the nicotinic acetylcholine receptor, 140 , 141 and the glutamate transporter GLT-1.”
Integrating virtual screening and combinatorial chemistry for accelerated drug discovery. (2011, methodology): “GDB has been used successfully in VS coupled with chemical synthesis and biological testing [39, 40].”
Visualisation and subsets of the chemical universe database GDB-13 for virtual screening (2011, background): “4 million virtual molecules up to 11 non-hydrogen atoms of C, N, O, F [12, 13], which was shown to provide a useful starting point for designing bioactive synthetic ligands [14–17].”