Cytoarchitecture and physical properties of cytoplasm: volume, viscosity, diffusion, intracellular surface area.

By K. Luby‐Phelps. International Review of Cytology, 2000

1,042 citations recorded by the source corpus.

Subfields: Biophysics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8ab6e77db31e01c58520ef666fe9ccfea80b6f0c

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Citations in the corpus

Visualization of the intracellular behavior of HIV in living cells (2002, background): “Because of the high viscosity of the cytoplasm, movement of these particles by diffusion is likely to be very limited (for review see Luby-Phelps, 2000).”
Investigating the robustness of the classical enzyme kinetic equations in small intracellular compartments (2009, neutral): “One of the outstanding differences between in vivo and in vitro conditions, is that in the former, biochemical reactions typically occur in minuscule reaction volumes [1].”
The role of cytoplasmic streaming in symplastic transport (2003, neutral): “Third, relative diffusion coefficients of various large molecules in cytoplasm have been measured (cf. Luby-Phelps 2000) and shown to be smaller than in aqueous solution but definitely not zero.”
The Acetate Switch (2005, background): “The biochemistry of crowded solutions differs from that which operates in dilute solution (277, 278).”
SINGLE-PARTICLE TRACKING (2009, background): “One problem with large labels is that their motion may be hindered by cellular structures such as the extracellular matrix [61], the cytoskeleton [62,63], or chromatin [64].”
Stochastic models of intracellular transport (2013, background): “…of the interior aqueous environment of cells (cytoplasm) and intracellular compartments such as the endoplasmic reticulum and mitochondria is that they are crowded with macromolecules and skeletal proteins, which occupy 10%−50% of the volume (Dix and Verkman, 2008; Fulton, 1982; Luby-Phelps, 2000).”
Polyploidy, the Nucleotype, and Novelty: The Impact of Genome Doubling on the Biology of the Cell (2019, background): “…the nucleus, the concept of “crowdedness” is critically important and has led to the need to modify if not outright reject the primacy of Brownian motion and diffusion as the driving force of cellular transport of at least some molecules (Agutter et al. 2000; Luby-Phelps 2000, 2013; Ellis 2001).”