Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

By A. Lavelle, Harry Sokol. Nature reviews: Gastroenterology & hepatology, 2020

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Bifidobacteria-mediated immune system imprinting early in life (2020, background): “…life due to antibiotic use lead to changes in the production of bacterial metabolites such as short-chain fatty acids (SCFAs) and other microbial-derived metabolites involved in immune maturation and homeostasis, as well as host energy metabolism, and intestinal integrity (Lavelle and Sokol, 2020).”
Gut microbiota-derived metabolites as central regulators in metabolic disorders (2020, background): “81 82 We have identified in a previous study, in both preclinical and clinical settings, that metabolic disorders are characterised by a reduced capacity of the microbiota to metabolise tryptophan into AhR agonists.”