X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity

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The voltage-gated potassium channels and their relatives (2002, background): “This concept is mirrored in the quite different architecture of channels designed to conduct the negatively charged chloride ions—these have the positive ends of multiple helices pointed towards the central ion sit”
Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels (2004, background): “Abolition of proton coupling by E148A mutation In ClC-ec1 a conserved glutamate residue, E148, lies close to a bound Cl - ion, occluding the extracellular side of the transport pathwa”
Membrane-protein topology (2006, background): “1b ) is a homodimer, and each monomer has a Cl − -specific channe”
Large-scale determination of previously unsolved protein structures using evolutionary information (2015, background): “…have been found in several transporter proteins and are frequently involved in ion binding ( Screpanti and Hunte, 2007 ); a similar arrangement of broken helices is also observed in structures of CLC chloride channels and glutamate transporter Glt ( Dutzler et al., 2002 ; Yernool et al., 2004 ).”
PDBTM: Protein Data Bank of transmembrane proteins after 8 years (2012, background): “aquaporins (22), potassium channels (23), chloride channels (24), etc.”