Water-soluble iron oxide nanocubes with high values of specific absorption rate for cancer cell hyperthermia treatment.

By P. Guardia, R. Di Corato, L. Lartigue, C. Wilhelm, Ana Espinosa, M. García-Hernández, F. Gazeau, L. Manna, T. Pellegrino. ACS Nano, 2012

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Prospects of nanoscience with nanocrystals. (2015, neutral): “473,474 Thus, SPIONs ful ﬁ ll theranostic purposes, ﬁ rst, by helping to diagnose tumor tissue by providing contrast in MRI to visualize it and, second, by facilitating therapy ( i.e. , tumor ablation) by local hyperthermia.”
Tuning the Magnetic Properties of Nanoparticles (2013, background): “The efficiency of heating for a magnetic material is described by the specific absorption rate (SAR), which is equal to the rate at which energy is absorbed per unit mass of the nanoparticles at a specific frequency [72] and is described as shown in Equation (4).”
Iron Oxide Nanoparticles: Diagnostic, Therapeutic and Theranostic Applications (2019, background): “observed a linear SAR dependence as a function of frequency (at a fixed amplitude) and a quadratic SAR dependence as a function of amplitude (at a fixed frequency) for water-soluble iron oxide nanocubes [15,115].”
Fe3O4 Nanoparticles: Structures, Synthesis, Magnetic Properties, Surface Functionalization, and Emerging Applications (2021, background): “Depending on the size, geometry, crystallinity, surface properties, and synthetic methods, the superparamagnetic–ferrimagnetic transition in Fe3O4 has been identified at approximately 20 nm [52], or even at ~30 nm [53].”