Integrins: bidirectional, allosteric signaling machines.

By R. Hynes. Cell, 2002

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E-cadherin–integrin crosstalk in cancer invasion and metastasis (2013, background): “By contrast, p120-catenin is reported to stabilise E-cadherin at the plasma membrane (Ireton et al., 2002) by controlling its cell surface levels through the regulation of cadherin trafficking (D’Souza-Schorey, 2005; Davis et al., 2003).”
Axis of evil: molecular mechanisms of cancer metastasis (2003, background): “Integrins are essential for progression because of their ability to mediate physical interactions with ECMs and their ability to regulate signaling pathways that control actin dynamics and cell movement (Hynes, 2002).”
SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. (2008, background): “Without the correct b integrin subunit, the a subunit is rapidly degraded (Hynes, 2002).”