Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes.
By Takamitsu Fujiwara, Y. Imamura, R. Margolis, J. Slakter, R. Spaide. American journal of ophthalmology-glaucoma, 2009
831 citations recorded by the source corpus.
PURPOSE To measure macular choroidal thickness (CT) in highly myopic eyes using enhanced depth imaging optical coherence tomography (OCT). DESIGN Retrospective, observational case series. METHODS Enhanced depth imaging OCT images were obtained in highly myopic eyes (> or =6 diopters [D]). Images of CT were obtained by positioning a spectral-domain OCT device close enough to the eye to acquire an inverted image. CT was measured from the outer border of the retinal pigment epithelium to the inner scleral border at 1000-mum intervals of a horizontal section from 3 mm temporal to the fovea to 3 mm nasal to the fovea. Statistical analysis was performed to evaluate CT at each location and to correlate CT with age and refractive error. RESULTS The mean age of the 31 patients (55 eyes) was 59.7 years (+/- 17.6 years; range, 24 to 90 years), and the mean refractive error was -11.9 D (+/- 3.7 D). The mean subfoveal CT was 93.2 microm (+/- 62.5 microm) and was correlated negatively with age (P = .006), refractive error (P < .001), and history of choroidal neovascularization (P = .013). Regression analysis suggested that subfoveal CT decreased by 12.7 mum for each decade of life and by 8.7 microm for each D of myopia. CONCLUSIONS The choroid in highly myopic eyes is very thin and undergoes further thinning with increasing age and degree of myopia. Abnormalities of the choroid may play a role in the pathogenesis of myopic degeneration.
Subfields: Ophthalmology
View Paper: https://www.semanticscholar.org/paper/89eb7c1de6ec2a727df91602c04db4ee0e560d8e
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Ophthalmology
Citations in the corpus
- Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis. (2015, background): “Firstly there is a reduction in choroidal thickness with age, axial length, and myopic refractive error, and the choroid is also thinner in females than inmales (Fujiwara et al., 2009; Ikuno et al., 2010; Li et al., 2011; Margolis and Spaide, 2009).”
- Diurnal variation of choroidal thickness in normal, healthy subjects measured by spectral domain optical coherence tomography. (2012, result): “Earlier studies have reported similar negative correlations between choroidal thickness and age, and axial length,(3,21,23,40,41,44) and a positive correlation with refractive error.(3,5,14) In this study, we found that the amplitude of choroidal thickness diurnal variation correlated significantly ”