生活習慣病とgenome-wide association study

By 田原康玄. 2015

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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin dosing: 2017 Update (2017, background): “This study concluded that African Americans who are heterozygous or homozygous for the rs12777823 A allele require a dose reduction of 7 or 9 mg/week, respectively.(7) Regression analysis showed that addition of this SNP improves the dosing algorithm published by the International Warfarin Pharmacog”
The Broad Scope of Health Effects from Chronic Arsenic Exposure: Update on a Worldwide Public Health Problem (2013, background): “A recent large, comprehensive genome-wide association study identified specific genetic variations associated with risk for skin lesions as well as differences in arsenic metabolism (Pierce et al. 2012).”