Wind-up of spinal cord neurones and pain sensation: much ado about something?

By J. Herrero, J. Laird, J. Lopez-Garcia. Progress in neurobiology, 2000

710 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Physiology

View Paper: https://www.semanticscholar.org/paper/89bda2837241170436189fef4075eb3e482bf5e2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Niels Birbaumer
2. R. Baron
3. Jonathan R. Wolpaw
4. Leonardo G. Cohen
5. Dennis J. McFarland
6. Joseph N. F. Mak
7. Eric W. Sellers
8. John P. Donoghue

In Physiology

1. Niels Birbaumer
2. Roger B. Fillingim
3. Rolf-Detlef Treede
4. R. Baron

Citations in the corpus

• Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Standardized protocol and reference values (2006, background): “Wind-up is a frequency dependent increase in excitability of spinal cord neurons that reaches a plateau after about five stimuli (Herrero et al., 2000), the perceptual correlate of which can be described by this ratio.”
• Sex, Gender, and Pain: A Review of Recent Clinical and Experimental Findings (2009, background): “It seems plausible that estrogenic enhancement of NMDA receptor excitability could contribute to more robust central sensitization among women than men.(186) These sex-related influences on NMDA receptor function could help explain sex differences in temporal summation (or ‘‘windup’’) of pain.”