Structure-brain exposure relationships.

By S. Hitchcock, L. Pennington. Journal of Medicinal Chemistry, 2006

632 citations recorded by the source corpus.

Subfields: Oncology, Pediatrics, Perinatology and Child Health, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/89a6da439ce154ee0099547e4f4bfe7015edf507

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Oncology

1. Marija R. Popović-Nikolić
2. Katarina Nikolic
3. Rona R. Ramsay
4. Maria Laura Bolognesi
5. John A. Arnott
6. Elisa Uliassi
7. S. Planey

In Spectroscopy

1. John A. Arnott
2. S. Planey

Citations in the corpus

• A perspective on multi-target drug discovery and design for complex diseases (2018, background): “The effectiveness of CNS drugs depends on drug penetration through the blood–brain barrier (BBB) between the blood capillaries and brain tissue, the extent of distribution of the drug in the brain, and the drug activities on the targets.”
• The influence of lipophilicity in drug discovery and design (2012, background): “Thus, over the years, consideration of lipophilicity has been relied on heavily in drug design for targeting the CNS; however, in addition to passive transport mechanisms, active influx or efflux mechanisms also influence movement of molecules across the BBB (for a review see [80]), and high lipophi”