Biofilm infections, their resilience to therapy and innovative treatment strategies

By U. Römling, C. Balsalobre. Journal of Internal Medicine, 2012

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Pseudomonas aeruginosa Biofilms (2020, background): “As a result, highly structured biofilms can be formed which is often identified in patients with chronic infections, such as chronic lung infection, chronic wound infection and chronic rhinosinusitis [7].”
Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence (2017, background): “Other P. aeruginosa biofilm associated infections include chronic wound infection, chronic otitis media, chronic rhinosinusitis, catheter-associated urinary tract infection, and contact lens-related keratitis (Römling and Balsalobre, 2012).”
Bacterial biofilm development as a multicellular adaptation: antibiotic resistance and new therapeutic strategies. (2013, background): “In the clinic, biofilm infections are usually treated with combinations of antibiotics [11,12,13 ,14].”
Biofilms: Microbial Cities of Scientific Significance (2014, background): “Researchers and scientific investigators have carried out several demonstrative studies to understand the molecular mechanisms of bacterial biofilms which is essential for the development of a suitable biofilm model which can be employed to perform in vivo studies to reveal innovative means of thera”