Sequencing pools of individuals — mining genome-wide polymorphism data without big funding

By Christian Schlötterer, R. Tobler, Robert Kofler, V. Nolte. Nature reviews genetics, 2014

704 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Development of multiple SNP marker panels affordable to breeders through genotyping by target sequencing (GBTS) in maize (2019, background): “Compared to chips, GBS can identify more variants across the genome and reduce the costs remarkably, but the unreliable imputation of missing data and the inevitable bias caused by restriction enzymes also make it unpractical to crop breeding (Schlötterer et al. 2014).”
Applications of next-generation sequencing to the study of biological invasions (2015, background): “However, analytical limitations do exist (see Schlötterer et al., 2014), mainly because a reduced representation of the genome may lead to data biases.”
What is Speciation Genomics? The roles of ecology, gene flow, and genomic architecture in the formation of species (2018, background): “For other applications that require large numbers of individuals, pooled sequencing (e.g. Pool-seq; Schlötterer et al., 2014) and low-coverage sequencing (Nielsen et al.”