Paroxetine for the prevention of depression induced by high-dose interferon alfa.

By D. Musselman, D. Lawson, Jane F. Gumnick, A. Manatunga, S. Penna, R. Goodkin, K. Greiner, C. Nemeroff, Andrew H. Miller. New England Journal of Medicine, 2001

1,119 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Pharmacology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/89789f87e26b98d60228a619a574837aeb041d45

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Citations in the corpus

Inflammation Causes Mood Changes Through Alterations in Subgenual Cingulate Activity and Mesolimbic Connectivity (2009, neutral): “In the present study, the correlation between peripheral cytokine levels (IL-6) and inflammation-associated mood deterioration did not reach significance, although there was a trend for those subjects showing the greatest IL-6 response to report a greater deterioration in total mood [t(15) = −1.”
Early-Life Adversity and Physical and Emotional Health across the Lifespan: A Neuro-Immune Network Hypothesis (2015, background): “In patients who receive inflammatory cytokines for treatment of hepatitis C or malignant melanoma, rates of depression are 30% to 50% (89,90).”
The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease. (2005, background): “[463] Musselman DL, Lawson DH, Gumnick JF, Manatunga AK, Penna S,”
Major depression after breast cancer: a review of epidemiology and treatment. (2008, background): “Antidepressant therapy has been shown to ameliorate depressive symptoms associated with administration of inflammatory cytokines [189,190] and elevated plasma IL-6 levels decline when patients with MDD are successfully treated with fluoxetine [191].”
Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system (2005, background): “The inflammatory cytokines, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α), induce anorexia and deficits in cognitive and motor function and may lead to major depression in chronically infected patients (7, 8) and cancer patients undergoing chemotherapy (7, 9).”
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression (2009, positive): “Nevertheless, in contradistinction to the prominence of depression following administration of innate immune cytokines such as interferon (IFN)-alpha to humans (12,13), administration of the T cell cytokine, IL-2, is not uncommonly associated with profound changes in mental status including psychosi”
Cytokine Targets in the Brain: Impact on Neurotransmitters and Neurocircuits (2013, background): “[27] Of note, many of the mood and anxiety symptoms induced by IFN-α can be blocked by pretreatment with selective serotonin reuptake inhibitors (SSRIs), indicating that these symptoms may be related to cytokine effects on serotonin metabolism.[27] Consistent with these data, patients with the short”
Depression sum-scores don’t add up: why analyzing specific depression symptoms is essential (2015, background): “This does not deny the possibility that a central mechanism may switch on multiple aspects of depression in some depressed individuals; that obviously occurs, for instance, as a result of interferon treatment that can cause anhedonia, concentration problems, fatigue, and sleep problems [117].”
Cytokines in Cancer Immunotherapy (2011, background): “In some studies of IFNdepression was highly significant and rare suicides were reported [47].”
Chronic psychological stress and the regulation of pro-inflammatory cytokines: a glucocorticoid-resistance model. (2002, background): “, 1999) and may contribute to depressive symptoms (Capuron, Ravaud, & Dantzer, 2000; Musselman et al., 2001), this could be a very fruitful line of research.”
Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior (2012, background): “…interferon-a (IFN-a) has also been found to induce depressive symptoms, with as many as 30–50% of IFN-atreated patients meeting the symptom criteria for major depression (according to the Diagnostic and Statistical Manual IV) depending on the dose (Musselman et al, 2001; Raison et al, 2005a, b).”
A visual analytics approach to understanding cycling behaviour (2012, neutral): “…timescale proposed by Nicholls and Ranger [2] can be used as a convenient non-dimensionalisation parameter for understanding the temporal development of the process: It is generally considered [1] that when the Oh number is less than 0.1 the droplet breakup is mostly influenced by the We number.”