Targeting the cancer epigenome for therapy

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Transcriptional Addiction in Cancer (2017, neutral): “Chromatin regulators function globally, so their dysregulation can also have profound effects on the gene expression program of cells (Jones et al., 2016).”
Precision Oncology: The Road Ahead (2017, background): “Along these lines, drugs are/have been developed to reprogram epigenetic marks and restore normal gene expression programs, such as various HDAC inhibitors [20], in addition to drugs that interfere with tumor-microenvironment crosstalk, including angiogenesis inhibitors [21] and immunotherapeutic ag”