T cells of Parkinson’s disease patients recognize α–synuclein peptides
By D. Sulzer, R. Alcalay, Francesca Garretti, L. Cote, E. Kanter, Julian Agin-Liebes, Christopher Liong, Curtis McMurtrey, W. Hildebrand, Xiaobo Mao and 14 more. Nature, 2017
690 citations recorded by the source corpus.
Genetic studies have shown the association of Parkinson’s disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson’s disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson’s disease. These responses may explain the association of Parkinson’s disease with specific major histocompatibility complex alleles.
Subfields: Cellular and Molecular Neuroscience, Neurology
View Paper: https://www.semanticscholar.org/paper/896b5db788d882998cc5b9c0e27dc0e3f8071301
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In Neurology
Citations in the corpus
- Alpha-synuclein in Parkinson’s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction (2023, background): “Interestingly, T cells were reported to respond to α-syn epitopes found in both extracellular native α-syn and fibrilized α-syn [74].”