Identification of a functional transposon insertion in the maize domestication gene tb1

By Anthony J. Studer, Qiong Zhao, J. Ross-Ibarra, John Doebley. Nature Genetics, 2011

711 citations recorded by the source corpus.

Genetic diversity created by transposable elements is an important source of functional variation upon which selection acts during evolution. Transposable elements are associated with adaptation to temperate climates in Drosophila, a SINE element is associated with the domestication of small dog breeds from the gray wolf and there is evidence that transposable elements were targets of selection during human evolution. Although the list of examples of transposable elements associated with host gene function continues to grow, proof that transposable elements are causative and not just correlated with functional variation is limited. Here we show that a transposable element (Hopscotch) inserted in a regulatory region of the maize domestication gene, teosinte branched1 (tb1), acts as an enhancer of gene expression and partially explains the increased apical dominance in maize compared to its progenitor, teosinte. Molecular dating indicates that the Hopscotch insertion predates maize domestication by at least 10,000 years, indicating that selection acted on standing variation rather than new mutation.

Subfields: Plant Science

View Paper: https://www.semanticscholar.org/paper/8963769149d9e82d705a48f059dd41207d658114

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In Plant Science

1. Shujun Ou
2. Ning Jiang
3. Steven M. L. Smith
4. Bing Wang
5. Jiayang Li

Citations in the corpus

• Benchmarking transposable element annotation methods for creation of a streamlined, comprehensive pipeline (2019, background): “Stowaway and 38 PIF/Harbinger transposons in rice (Oryza sativa), for instance, are associated with subspecies39 specific hotspots of recombination [5], and specific TE insertions have been associated with 40 plant architecture [6] and flowering time [7] in maize, generating phenotypic variation imp”
• Genetic Regulation of Shoot Architecture. (2018, background): “As such, subsequent selection acted on this existing variant rather than on a new mutation (157).”
• Transposable elements contribute to activation of maize genes in response to abiotic stress (2014, background): “There are clear examples of TE insertions that are linked to functionally relevant alleles in maize such as Tb1 [42] Vgt1 [43] and ZmCCT [44].”