A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

By Takeshi Tanoue, S. Morita, D. Plichta, Ashwin N. Skelly, W. Suda, Y. Sugiura, S. Narushima, H. Vlamakis, Iori Motoo, K. Sugita and 18 more. Nature, 2019

1,015 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/88f185ce3b8d9edae33f405188e3131caa3463a7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Rob Knight
2. L. Zitvogel
3. J. Wargo
4. Guido Kroemer
5. L. Galluzzi

In Molecular Biology

1. Rob Knight
2. Jeff Hasty
3. L. Zitvogel
4. J. Wargo
5. Noah Fierer
6. C. Lauber
7. Micah Hamady
8. Catherine A. Lozupone

In Oncology

1. L. Zitvogel
2. J. Wargo

Citations in the corpus

• Comprehensive review of targeted therapy for colorectal cancer (2020, background): “Several strains of bacteria were related to the drug response, and further experiments showed that colonization by a combination of 11 strains of bacteria in germ-free mice might have enhanced the efficacy of immune checkpoint modulators, partially because the new bacterial infection led to stronger”
• The microbiome and human cancer (2021, background): “For example, Tanoue and colleagues identified an 11-bacteria cocktail that increased tumor antigen–specific CD8 IFN-g T cells in the context of immune checkpoint blockade that were not cross-reactive with microbial antigens and did not originate from the colon (84).”