Ambient Particulate Pollutants in the Ultrafine Range Promote Early Atherosclerosis and Systemic Oxidative Stress

By J. Araujo, Berenice Barajas, M. Kleinman, Xu-ping Wang, Brian J. Bennett, K. Gong, M. Navab, J. Harkema, C. Sioutas, Aldons J. Lusis and 1 more. Circulation Research, 2008

605 citations recorded by the source corpus.

Subfields: Global and Planetary Change, Health, Toxicology and Mutagenesis

View Paper: https://www.semanticscholar.org/paper/88ee44ac5f5637b85a1e1bbe9b9b0aee31457f84

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In Health, Toxicology and Mutagenesis

1. Tian Xia
2. A. Schneider
3. Ken Donaldson
4. A. Nel
5. Annette Peters
6. Haibin Shi
7. M. Liong
8. Joanne I. Yeh

Citations in the corpus

• Health effects of particulate air pollution: A review of epidemiological evidence (2011, background): “A more recent study in apolipoprotein E-deficient mice showed that exposure to UFP (particle diameter 0.18 µm) lead to larger early atherosclerotic lesions in the animals than exposure to PM 2.5 or filtered air (Araujo et al., 2008).”
• Air Pollution and Cardiovascular Disease: JACC State-of-the-Art Review. (2018, background): “5, these generally show equal or, in some cases, larger effects, with at least 1 study showing that exposure of apolipoprotein E knockout (ApoE / ) mice to ultrafine particles resulted in greater atherosclerosis (110).”
• Comparison of the Mechanism of Toxicity of Zinc Oxide and Cerium Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties (2008, positive): “We have also shown that the hierarchical stress paradigm can be applied to the study and prediction of the adverse health effects of ambient ultrafines in animal disease models.(13,14) For instance, we have demonstrated that the higher oxidant potential of ambient ultrafine particles (aerodynamic di”
• Understanding biophysicochemical interactions at the nano-bio interface. (2009, background): “Although it is difficult at present to quantify reactive surface areas accurately, studies of the pro-oxidative potentials of ambient ultrafine particles under abiotic and cellular conditions and how they relate to pro-oxidative pathogenic events (for example atherosclerosis) in animals are examples”
• Adverse cardiovascular effects of air pollution (2009, background): “5 could have a greater atherogenic effect than the fine fraction—exposure to ultrafine particulate matter rich in polycyclic aromatic hydrocarbons produced more inflammation, systemic oxidative stress, and atheroma formation than the fine fraction or filtered air in apolioprotein-E-knockout mice”