Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factors.

By C. Silliman, L. Boshkov, Z. Mehdizadehkashi, David J. Elzi, W. Dickey, L. Podlosky, G. Clarke, D. Ambruso. Blood, 2003

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Transfusion-related acute lung injury. (2005, methodology): “In addition, the roles of IL-6 and IL-8 were examined; each increased during storage, but only IL-6 was significantly increased in the TRALI patients compared with the pretransfusion sample.(12) Thus, in this series, TRALI was caused by 2 events.”
Guidelines for the use of fresh‐frozen plasma, cryoprecipitate and cryosupernatant (2004, background): “According to some authors, TRALI develops in two steps ( Silliman et al, 2003 ).”
Transfusion-related acute lung injury: definition and review. (2005, background): “6% of TRALI reactions in the University of Alberta study, and neutrophil priming activity was greater in implicated units than in control units (12).”
Toward an understanding of transfusion‐related acute lung injury: statement of a consensus panel (2004, methodology): “One set of investigators has identified increased neutrophil priming activity in stored blood components as an etiologic factor in some cases of TRALI.(6,12) This activity is assessed by adding plasma or serum (from a stored blood component or the recipient) to an assay system containing fresh neutr”