‘New Trends for Metal Complexes with Anticancer Activity’
By Pieter C. A. Bruijnincx, P. Sadler. Current Opinion in Chemical Biology, 2008
1,236 citations recorded by the source corpus.
Summary Medicinal inorganic chemistry can exploit the unique properties of metal ions for the design of new drugs. This has, for instance, led to the clinical application of chemotherapeutic agents for cancer treatment, such as cisplatin. The use of cisplatin is, however, severely limited by its toxic side effects. This has spurred chemists to employ different strategies in the development of new metal-based anticancer agents with different mechanisms of action. Recent trends in the field are discussed in this review. These include the more selected delivery and/or activation of cisplatin-related prodrugs and the discovery of new non-covalent interactions with the classical target, DNA. The use of the metal as scaffold rather than reactive centre and the departure from the cisplatin paradigm of activity towards a more targeted, cancer cell-specific approach, a major trend, are discussed as well. All this, together with the observation that some of the new drugs are organometallic complexes, illustrates that exciting times lie ahead for those interested in ‘metals in medicine’.
Subfields: Oncology, Organic Chemistry
View Paper: https://www.semanticscholar.org/paper/88a8153c8958ac7f76b4e82b38a07db10a45cae1
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Citations in the corpus
- Metal complexes in cancer therapy – an update from drug design perspective (2017, background): “They are frequently found in the enzyme catalytic domain(9) and are involved in multiple biological processes, from the exchange of electrons to catalysis and structural roles.(9) They are extensively used in cellular activities.”
- Metals in protein structures: a review of their principal features (2010, background): “Cisplatin, cis-[PtCl2(NH3)2], is used in cancer treatment, and its therapeutic effect is probably due to its interaction with DNA which disrupts the double helix structure (112, 113).”