Global Burden of 5 Major Types Of Gastrointestinal Cancer
By M. Arnold, C. Abnet, R. Neale, J. Vignat, Edward L. Giovannucci, K. McGlynn, F. Bray. Gastroenterology, 2020
1,740 citations recorded by the source corpus.
Background & Aims: There were an estimated 4.8 million new cases of gastrointestinal (GI) cancers and 3.4 million related deaths, worldwide, in 2018. GI cancers account for 26% of the global cancer incidence and 35% of all cancer-related deaths. We investigated the global burden from the 5 major GI cancers as well as geographic and temporal trends in cancer-specific incidence and mortality. Methods: Data on primary cancers of the esophagus, stomach, colorectum, liver, and pancreas were extracted from the GLOBOCAN database for the year 2018, as well as from the Cancer Incidence in 5 Continents series, and the World Health Organization mortality database from 1960 onward. Age-standardized incidence and mortality rates were calculated by sex, country, and level of human development. Results: We observed geographic and temporal variations in incidence and mortality for all 5 types of GI cancers. Esophageal, gastric, and liver cancers were more common in Asia than in other parts of the world, whereas of the burden from colorectal and pancreatic cancers was highest in Europe and North America. There was a uniform decrease in gastric cancer incidence but an increasing incidence of colorectal cancer in formerly low-incidence regions over the studied time period. We found slight increases in incidence of liver and pancreatic cancer in some high-income regions. Conclusions: Although the incidence of some GI cancer types has decreased, this group of malignancies continues to pose major challenges to public health. Primary and secondary prevention measures are important for controlling these malignancies—most importantly reducing consumption of tobacco and alcohol, obesity control, immunizing populations against hepatitis B virus infection, and screening for colorectal cancer.
Subfields: Pulmonary and Respiratory Medicine, Surgery
View Paper: https://www.semanticscholar.org/paper/889b172fbbac7560d2993f17781c6e4e05cae2b7
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Citations in the corpus
- Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries (2024, background): “63,125,126 Vaccination against HBV has markedly reduced the prevalence of HBV infection and the incidence of HCC in high ‐ risk countries in East Asia, where it was first introduced in the early 1980s.”
- Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy (2023, background): “Furthermore, the increases are not uniform across all countries, as supported by the current stable or even downward trends in HCC incidence and mortality rates in some countries, including China and the USA 61,81 .”
- Global colorectal cancer burden in 2020 and projections to 2040 (2021, background): “Declined or stabilized CRC incidence has been observed in limited countries with very high human development [12, 13], that mainly benefits from the healthier lifestyle and the establishment of screening program a decade ago [14].”