Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis.

By M. Mark, N. Ghyselinck, P. Chambon. Annual Review of Pharmacology and Toxicology, 2006

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Retinoic acid in development: towards an integrated view (2008, background): “Targeted disruption of the murine RA receptor (RAR) genes revealed mainly redundant roles; homozygous disruption of two RARs was necessary to induce abnormalities that recapitulate (and even add to) those of VAD syndrome (see Ref”
Thymine DNA Glycosylase Is Essential for Active DNA Demethylation by Linked Deamination-Base Excision Repair (2011, neutral): “Similarly, some other specific phenotypic features in Tdg-null embryos (OFT septation defects, hypoplastic myocardium, abnormal great arteries derived from branchial arches, delayed limbs) resemble those of embryos deficient in various RAR and RXR genes (Mark et al., 2006), or hypomorphic for retina”
Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes (2015, positive): “Retinoic acid signaling is involved in morphogenesis, growth, differentiation, and tissue homeostasis, which include genital tubercle development and different phases of spermatogenesis (Liu et al. 2012; Mark et al. 2006, 2015).”