The Effects of Estrogen-Responsive Element- and Ligand-Induced Structural Changes on the Recruitment of Cofactors and Transcriptional Responses by ERα and ERβ

By P. Yi, M. D. Driscoll, Jing Huang, S. Bhagat, R. Hilf, R. Bambara, M. Muyan. 2002

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Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors α and β by coactivators and corepressors (2004, methodology): “Thus, the effects of coregulatory proteins on E2-activated transcription is not governed solely by the affinity of ER-ERE interaction, but we suggest reflects ERE-mediated alterations in ER conformation (Klinge et al. 2001, Ramsey & Klinge 2001, Yi et al. 2002 ) that we propose impact ER-coactivato”
Estrogen signaling multiple pathways to impact gene transcription. (2006, background): “This explains, at least in part, how the sequence of the response element can be one important determinant of the extent to which ERs can activate gene expression [52-55].”
Estrogen receptor signaling mechanisms (2019, background): “This moderately explains why differences in ERE sequences, such as those resulting from inter-individual gene variability or mutations, can affect the activation of gene expression (Loven, Wood, & Nardulli, 2001; Yi et al., 2002).”