The mechanism of phospholipase C-γ1 regulation

By M. J. Kim, Euikyung Kim, Sung Ho Ryu, P. Suh. Experimental and Molecular Medicine, 2000

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Phospholipase C (PLC)1 hydrolyzes phosphatidylinositol 4,5-bisphosphate to generate the second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces a transient increase in intracellular free Ca2+, while DAG directly activates protein kinase C. Upon stimulation of cells with growth factors, PLC-γ1 is activated upon their association with and phosphorylation by receptor and non-receptor tyrosine kinases. In this review, we will focus on the activation mechanism and regulatory function of PLC-γ1.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8804d7e5f08b1a3ae0415fa6d559ce4d1d250dbb