C-Reactive Protein Increases Plasminogen Activator Inhibitor-1 Expression and Activity in Human Aortic Endothelial Cells: Implications for the Metabolic Syndrome and Atherothrombosis

By Sridevi Devaraj, Dan Xu, I. Jialal. Circulation, 2003

701 citations recorded by the source corpus.

Subfields: Cancer Research, Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/87a18c7ee380dc4cd09bb2422e38bfb164944c78

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In Cancer Research

1. P. Ridker
2. S. Verma
3. C. Esmon

In Epidemiology

1. P. Ridker
2. N. Rifai
3. Christian K. Roberts
4. R. J. Barnard
5. S. Verma
6. Peter Libby
7. L. Melvin
8. S. Grundy

In Immunology

1. P. Ridker
2. S. Verma
3. Peter Libby

Citations in the corpus

• Adipokines: molecular links between obesity and atheroslcerosis. (2005, background): “CRP 2 NO by destabilizing eNOS mRNA and decreasing protein expression (112) 1 PAI-1 expression and activity in endothelial cells (19) 1 ET-1 and IL-6 release (112) CRP levels correlate with metabolic syndrome and predicts future CHD (90) 1 VCAM-1, ICAM-1, selectins, and MCP-1 in EC (12) Predicts the”
• Effects of exercise and diet on chronic disease. (2005, background): “Elevated CRP is associated with decreased nitric oxide (NO) bioavailability in human endothelial cells (395, 396), induces plasminogen activator inhibitor (82), and is independently Invited Review”
• The interactions between inflammation and coagulation (2005, background): “CRP has now been shown to facilitate monocyte–endothelial cell interactions (Han et al, 2004) and to promote plasminogen activator inhibitor-1 (PAI1) and tissue factor (Cermak et al, 1993; Devaraj et al, 2003) formation.”
• C-reactive protein and the risk of developing hypertension. (2003, background): “Higher levels of C-reactive protein also play an important role in the induction of plasminogen activator inhibitor 1 (PAI-1), a marker of impaired fibrinolysis and atherothrombosis.(15,31) The recent novel finding that C-reactive protein increases PAI-1 expression and activity in human aortic endot”
• The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults. (2007, background): “hs-CRP concentration has been reported to induce PAI-1 expression and activity in human aortic endothelial cells ( 39 ), whereas increased PAI-1 expression was demonstrated in the media layer of the arterial segment with atherosclerotic changes (40) and considered as an acute reaction of the vascula”