Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover

By J. Almeida, D. Price, L. Papagno, Z. A. Arkoub, D. Sauce, E. Bornstein, Tedi E. Asher, A. Samri, A. Schnuriger, I. Theodorou and 7 more. Journal of Experimental Medicine, 2007

789 citations recorded by the source corpus.

The key attributes of CD8+ T cell protective immunity in human immunodeficiency virus (HIV) infection remain unclear. We report that CD8+ T cell responses specific for Gag and, in particular, the immunodominant p24 epitope KK10 correlate with control of HIV-1 replication in human histocompatibility leukocyte antigen (HLA)–B27 patients. To understand further the nature of CD8+ T cell–mediated antiviral efficacy, we performed a comprehensive study of CD8+ T cells specific for the HLA-B27–restricted epitope KK10 in chronic HIV-1 infection based on the use of multiparametric flow cytometry together with molecular clonotypic analysis and viral sequencing. We show that B27-KK10–specific CD8+ T cells are characterized by polyfunctional capabilities, increased clonal turnover, and superior functional avidity. Such attributes are interlinked and constitute the basis for effective control of HIV-1 replication. These data on the features of effective CD8+ T cells in HIV infection may aid in the development of successful T cell vaccines.

Subfields: Immunology, Virology

View Paper: https://www.semanticscholar.org/paper/87824449294809543e2de0794989402542f4c731

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. F. Sallusto
2. Mario Roederer
3. V. Appay
4. D. Sauce
5. Rafi Ahmed
6. A. Lanzavecchia

In Virology

1. Mario Roederer
2. F. Sallusto
3. V. Appay
4. D. Sauce

Citations in the corpus

• Immune activation and inflammation in HIV‐1 infection: causes and consequences (2008, background): “Due to their sensitivity for the antigen, high-avidity T cells may be particularly sensitive to such stimulationdriven depletion [73].”
• Phenotype and function of human T lymphocyte subsets: Consensus and issues (2008, result): “However, subsequent studies showed no consensus on this theory: HIV-specific CD8 T cells associated with superior control of HIV were also characterized by a CD271 CCR72CD45RA2 phenotype (47,63); and in the setting of CMV disease, the majority of CMV-specific CD8 T cells displayed also a CD272CCR72C”