Effect of nanoparticle surface charge at the plasma membrane and beyond

By R. Arvizo, Oscar R. Miranda, M. Thompson, C. Pabelick, Resham Bhattacharya, J. D. Robertson, Vincent Rotello, Y. S. Prakash, P. Mukherjee. Nano letters (Print), 2010

600 citations recorded by the source corpus.

Herein, we demonstrate that the surface charge of gold nanoparticles (AuNPs) plays a critical role in modulating membrane potential of different malignant and non-malignant cell types and subsequent downstream intracellular events. The findings presented here describe a novel mechanism for cell-nanoparticle interactions and AuNP uptake: modulation of membrane potential and its effect on intracellular events. These studies will help understand the biology of cell-nanoparticle interactions and facilitate the engineering of nanoparticles for specific intracellular targets.

Subfields: Biomaterials, Electronic, Optical and Magnetic Materials, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/874a95b96c772eb8c3f3f75902231756a7e79189

Citations in the corpus

• The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles (2012, unknown): “Arviso et al suggested perturbation of the membrane potential by positively charged gold particles with flipping of membrane areas as the mode of uptake.(146) An orderly arrangement of hydrophilic and hydrophobic ligands at the particle surface facilitates passive entry for gold NPs and lipid partic”