Endothelial function testing as a biomarker of vascular disease.

By S. Verma, M. Buchanan, T. Anderson. Circulation, 2003

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Pathophysiology of Atherosclerosis (2022, background): “Briefly, when ECs lose their ability to maintain homeostasis, vessel walls are predisposed to vasoconstriction, lipid infiltration, leukocyte adhesion, platelet activation, and oxidative stress, among other things [23,24].”
Adverse cardiovascular outcomes in women with nonobstructive coronary artery disease: a report from the Women's Ischemia Syndrome Evaluation Study and the St James Women Take Heart Project. (2009, background): “It has been hypothesized that this abnormal endothelial response may be the earliest marker of vascular disease, representing a critical step in atherosclerosis.(29,30) The mechanism of this impaired endothelial response appears to be due to imbalance between endotheliumderived vasodilators that hav”