Does Inbreeding and Loss of Genetic Diversity Decrease Disease Resistance?

By D. Spielman, Barry W. Brook, D. Briscoe, R. Frankham. Conservation Genetics, 2004

394 citations recorded by the source corpus.

Subfields: Insect Science, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8724a725b5b0b7e4d5381bad473c9b3f2107a519

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Insect Science

1. T. Smith

In Molecular Biology

1. L. Möller
2. L. Beheregaray
3. R. Bijlsma
4. Cino Pertoldi
5. Volker Loeschcke
6. T. Smith
7. J. Wiszniewski

Citations in the corpus

• Decreased immunocompetence in a severely bottlenecked population of an endemic New Zealand bird (2007, background): “…stress, disease and extinction, as reduced genetic variation in inbred individuals could lead to their immune systems being less adaptable or defective due to the loss of specific resistance alleles (O’Brien et al., 1985; Thorne & Williams, 1988; Spielman et al., 2004; Swinnerton et al., 2005).”
• Remarkably low genetic diversity and strong population structure in common bottlenose dolphins (Tursiops truncatus) from coastal waters of the Southwestern Atlantic Ocean (2014, background): “Although there is no evidence of inbreeding depression for bottlenose dolphins in this region, the possibility of inbreeding in the small LGN community (Table 1) may, in the long-term, be detrimental to its viability since inbreeding can increase vulnerability to environmental stressors (O’Brien et ”
• Maintaining tiger connectivity and minimizing extinction into the next century: Insights from landscape genetics and spatially-explicit simulations (2017, background): “Small, isolated populations have known genetic consequences, including low variation (Frankham 1996; Boersen et al. 2003), increased inbreeding and increased disease susceptibility (Spielman et al. 2004; Trinkel et al. 2011), and heightened extinction risk (Saccheri et al. 1998).”
• Conservation genetics in a globally changing environment: present problems, paradoxes and future challenges (2007, background): “…range can produce fragmentations of the populations increasing the eVects of random genetic processes which can lead to a reduction of the eVective population size (Ne), of the genetic variability and of the evolutionary potential (Bijlsma et al. 2000; Hedrick 2000; Spielman et al. 2004a, b).”
• Multiple paternity and sperm storage lead to increased genetic diversity in Anolis lizards (2007, background): “If progeny encounter novel pathogens (Palmer and Oldroyd, 2003; Spielman et al., 2004; Pearman and Garner, 2005), or other unpredictable environmental conditions, then diversifying progeny genotypes may ensure that at least some offspring survive to adulthood.”