Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice.
By S. Khare, I. Sarosi, X. Xia, Susan McCabe, K. Miner, I. Solovyev, N. Hawkins, M. Kelley, D. Chang, Gwyneth Van and 6 more. Proceedings of the National Academy of Sciences of the United States of America, 2000
634 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/86cda2f12ed02af444db0114832b1572015abbb6
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
Citations in the corpus
- Baff Mediates Survival of Peripheral Immature B Lymphocytes (2000, background): “In contrast, B cell development in the BM is not affected by the BAFF transgene (18, 26, 27).”
- Control of lymphocyte development by nuclear factor-κB (2005, positive): “Autoimmune diseases might be initiated in malfunctioning lymphocytes when apoptotic pathways that are activated by self-antigens are blocked by abnormal activation of NF-κB, enabling the survival of self-reactive cell”
- BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells (2002, background): “Humans with various autoimmune diseases have increased concentrations of BAFF in ser”
- Cutting Edge: A Role for B Lymphocyte Stimulator in Systemic Lupus Erythematosus1 (2001, background): “Prolonged survival and hyperactivity of the B cells contributes to the disease phenotype (6, 7).”
- Importance of Cellular Microenvironment and Circulatory Dynamics in B Cell Immunotherapy1 (2005, background): “Overexpression of a soluble form of BAFF/BLyS/TALL-1 in mice results in B cell hyperplasia, hypergammaglobulinemia, and autoimmune lupus-like syndrome (21).”
- Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome. (2002, result): “Similar to patients with SS, BAFF Tg mice secreted large amounts of rheumatoid factors and Ig’s (23, 40).”