Exploring α7-Nicotinic Receptor Ligand Diversity by Scaffold Enumeration from the Chemical Universe Database GDB.

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Visualisation and subsets of the chemical universe database GDB-13 for virtual screening (2011, background): “4 million virtual molecules up to 11 non-hydrogen atoms of C, N, O, F [12, 13], which was shown to provide a useful starting point for designing bioactive synthetic ligands [14–17].”
The enumeration of chemical space (2012, background): “We have reported ligand discovery examples for inhibitors of the NMDA glycine site, 138 , 139 the nicotinic acetylcholine receptor, 140 , 141 and the glutamate transporter GLT-1.”