Cytochrome p450 and chemical toxicology.

By F. Guengerich. Chemical Research in Toxicology, 2008

1,652 citations recorded by the source corpus.

Subfields: Computational Theory and Mathematics, Oncology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/869920cfec844394b8d8c2b05ddd1e64e5ff4c71

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Computational Theory and Mathematics

1. M. Schwab
2. Ulrich M. Zanger
3. N. Cedergreen
4. John A. Arnott
5. S. Planey

In Oncology

1. M. Schwab
2. Ulrich M. Zanger
3. N. Cedergreen
4. John A. Arnott
5. S. Planey

In Pharmacology

1. M. Schwab
2. Ulrich M. Zanger
3. N. Cedergreen
4. John A. Arnott
5. S. Planey

Citations in the corpus

• The influence of lipophilicity in drug discovery and design (2012, background): “The CYP (cytochrome p450) family of enzymes comprise a large and diverse group that primarily function in drug metabolism and account for about 75% of the total number of different metabolic reactions in vivo [103].”
• Fast Bundle Algorithm for Multiple-Instance Learning (2012, neutral): “In the image retrieval application [19], images (bags) are ranked with features computed for the segments (items).”
• Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. (2013, background): “The cytochromes P450 (CYPs) constitute the major enzyme family capable of catalyzing the oxidative biotransformation of most drugs and other lipophilic xenobiotics and are therefore of particular relevance for clinical pharmacology (Nelson, 2004; Guengerich, 2008; Zanger et al., 2008).”
• Polycyclic aromatic hydrocarbons: from metabolism to lung cancer. (2015, background): “CYPs account for 75% of the total metabolic enzymes for the various xenobiotics humans are exposed to everyday (Guengerich, 2008), and they are the major metabolic enzymes that catalyze the oxidation of organic substances such as PAHs.”
• Quantifying Synergy: A Systematic Review of Mixture Toxicity Studies within Environmental Toxicology (2014, background): “Azole fungicides are known inhibitors of a wide range of P450 monooxygenases, which are enzymes responsible for the phase I metabolization of lipophilic compounds [49], together with a range of biosynthesis processes in both plants and animals [50,51].”