Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

By L. Otterbein, F. Bach, J. Alam, M. Soares, Hong-tao Lu, M. Wysk, R. Davis, R. Flavell, A. Choi. Nature Medicine, 2000

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Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice (2005, background): “The increased expression of this antioxidant gene has been shown to inhibit TNF- (31).”
Pharmacological and Clinical Aspects of Heme Oxygenase (2008, unknown): “The activation of both sGC and p38 MAPK has been implicated in the suppression of inflammatory cytokines by HO-1/CO activation (Otterbein et al., 2000; Zhan et al., 2003).”
Heme oxygenase-1: from bench to bedside. (2005, background): “Proc Natl Acad Sci USA 1996;93(19):10393-10398.”
When NRF2 Talks, Who's Listening? (2010, unknown): “CO can repress the formation of TNF-a, IL-1b, and macrophage inflammatory protein-1b and increase IL-10 after LPS stimulation (110).”
Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications (2005, background): “At this concen- tration range, CO inhibited the production of proinflammatory cytokines, such as TNF- , MIF and interleukin-1, from macrophages (Otterbein et al., 2000) and the secretion of interleukin-2 from the activated T cells (Pae et al., 2004).”