Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist.

By W. Liles, H. Broxmeyer, Elin Rodger, B. Wood, K. Hübel, S. Cooper, G. Hangoc, G. Bridger, G. W. Henson, G. Calandra and 1 more. Blood, 2003

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Interleukin-6 in acute exercise and training: what is the biological relevance? (2006, background): “Activation of TLRs on these antigen presenting cells (APCs) results in both the activation of innate immune responses by inducing antimicrobial activity (3, 88), the production of inflammatory cytokines including IL-1β, IL-6, IL-8, and TNF-α (8, 48, 58).”
Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist (2005, background): “Mobilization of CD34 cells with 240 g AMD3100/kg is equal to or slightly better than with a 160 g/kg dose (31).”
Cancer-related inflammation: common themes and therapeutic opportunities. (2012, background): “Unexpectedly, AMD3100 was found to mobilize CD34+ stem cells from the bone marrow [80].”