Biodemography of human ageing

By James W. Vaupel. Nature, 2010

1,003 citations recorded by the source corpus.

Human senescence has been delayed by a decade. This finding, documented in 1994 and bolstered since, is a fundamental discovery about the biology of human ageing, and one with profound implications for individuals, society and the economy. Remarkably, the rate of deterioration with age seems to be constant across individuals and over time: it seems that death is being delayed because people are reaching old age in better health. Research by demographers, epidemiologists and other biomedical researchers suggests that further progress is likely to be made in advancing the frontier of survival — and healthy survival — to even greater ages.

Subfields: Aging, Demography, Health, Toxicology and Mutagenesis

View Paper: https://www.semanticscholar.org/paper/860ea607f1c0a34c99ebe46ebe4023407394a377

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Citations in the corpus

Operationalization of Frailty Using Eight Commonly Used Scales and Comparison of Their Ability to Predict All‐Cause Mortality (2013, background): “What mark does the patient give himself/herself for physical fitness? (scale 0 to 10) 7–10 = 0; 0–6 = 1 How often do you engage in activities that require a low or moderate level of energy such as gardening, cleaning the car, or doing a walk? (1) More than once a week; (2) Once a week; (3) One to th”
Mortality and morbidity trends: is there compression of morbidity? (2011, background): “Even death rates among people above age 100 have declined significantly in recent years leading to an increasing number of centenarians (Kannisto, Lauritsen, Thatcher, & Vaupel, 1994; Robine, Saito, & Jagger, 2003; Vaupel, 2010).”
Human life is unlimited – but short (2017, background): “Box 1 of Vaupel (2010) gives an introduction to the important explanation of mortality at high age as resulting from a mixture of subpopulations with different frailty.”
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging (2017, background): “With life expectancy projected to increase in the foreseeable future (Vaupel, 2010), it is important to develop strategies to extend and restore healthspan.”