The vagus nerve and the inflammatory reflex—linking immunity and metabolism
By Valentin A. Pavlov, Kevin J. Tracey. Nature Reviews Endocrinology, 2012
884 citations recorded by the source corpus.
The vagus nerve has an important role in regulation of metabolic homeostasis, and efferent vagus nerve-mediated cholinergic signalling controls immune function and proinflammatory responses via the inflammatory reflex. Dysregulation of metabolism and immune function in obesity are associated with chronic inflammation, a critical step in the pathogenesis of insulin resistance and type 2 diabetes mellitus. Cholinergic mechanisms within the inflammatory reflex have, in the past 2 years, been implicated in attenuating obesity-related inflammation and metabolic complications. This knowledge has led to the exploration of novel therapeutic approaches in the treatment of obesity-related disorders.
Subfields: Cardiology and Cardiovascular Medicine, Endocrine and Autonomic Systems, Neurology
View Paper: https://www.semanticscholar.org/paper/86034ed3e3d39531e6956c7fb8061c4a9f725aa4
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cardiology and Cardiovascular Medicine
In Endocrine and Autonomic Systems
- D. Quintana
- J. Chalmers
- Andrew H. Kemp
- Sigrid Breit
- Maree J. Abbott
- Aleksandra Kupferberg
- G. Hasler
- G. Rogler
In Neurology
- D. Quintana
- J. Chalmers
- Andrew H. Kemp
- Sigrid Breit
- Maree J. Abbott
- Aleksandra Kupferberg
- G. Hasler
- G. Rogler
Citations in the corpus
- Wireless Recording in the Peripheral Nervous System with Ultrasonic Neural Dust. (2016, neutral): “Recent technological advances (Boretius et al., 2010; Delivopoulos et al., 2012) and fundamental discoveries (Bhadra and Kilgore, 2005; Pavlov and Tracey, 2012; Rosas-Ballina et al., 2011) have renewed interest in implantable systems for interfacing with the peripheral nervous system.”
- Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018, background): “The inflammation-sensing and inflammation-suppressing functions outlined above provide the principal components of the inflammatory reflex (71).”
- Anxiety Disorders are Associated with Reduced Heart Rate Variability: A Meta-Analysis (2014, background): “The mechanism underpinning the relationship between mental and physical health may, in part, relate to impairment in vagal nerve activity leading to a dysregulation of inflammatory processes (11, 12).”