Non-eosinophilic asthma: importance and possible mechanisms

By J. Douwes, P. Gibson, J. Pekkanen, N. Pearce. Thorax, 2002

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Eosinophils: Biological Properties and Role in Health and Disease (2008, background): “…in eosinophils in the tissues, blood, and bone marrow are a hallmark of most asthma phenotypes and, in general, elevated numbers correlate with disease severity (although ‘‘noneosinophilic/nonneutrophilic’’ asthma is characteristic of bacterial, viral, and pollutant triggers) (Douwes et al. 2002).”
Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations (2006, result): “The more common occurrence of noneosinophilic exacerbations in both groups unaffected by the control of eosinophilia might have been suspected from some previous observations [6, 33, 34 ].”
Traffic, Susceptibility, and Childhood Asthma (2006, background): “…studies indicate that nonallergic asthma (without airway eosinophilia or atopy) may account for as much as half of all asthma (Beasley et al. 2001; Douwes et al. 2002; Pearce et al. 1999), and it has been suggested that risk factors for this asthma phenotype, including particulate air pollution,…”