Key roles of adjuvants in modern vaccines

By S. Reed, M. Orr, Christopher B. Fox. Nature Medicine, 2013

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Vaccine adjuvants: mechanisms and platforms (2023, background): “They have shown to enhance the strength, breadth, and persistence of immune responses in preclinical and clinical studies.(8) Although adjuvants have long been widely used in vaccines, the mechanisms by which they enhance immune responses have not been well characterized.”
Peptide Vaccine: Progress and Challenges (2014, background): “Of the synthetic polyesters, polylactides (PLA), polyglycolides or polyglocolic acid (PGA) and their copolymers poly(lactide-co-glycolide) PLGA are US FDA approved for use in humans and have been tested for toxicity and safety in extensive animal studies [3, 92] .”