Delivery materials for siRNA therapeutics.

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Nanogels: an overview of properties, biomedical applications and obstacles to clinical translation (2015, background): “Thus, the purpose of prolonging the half-life of such agents is defeated [224,225], and the therapeutic agents are cleared by the kidney quite quickly after the disruption of the carrier system [118].”
Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper (2015, background): “Viral and cationic carriers are potentially unsafe because of the uncontrolled integration of viral material or toxicity, respectively (222).”