Probing the limits to positional information.

By Thomas Gregor, David W. Tank, E. Wieschaus, William Bialek. Cell, 2007

704 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Fundamental Limits to Cellular Sensing (2015, background): “Recent experiments suggest that the precision of the embryonic development of the fruitfly Drosophila is close to the limit set by the available number of regulatory proteins [27,32,39,78].”
Cellular Decision-Making and Biological Noise: From Microbes to Mammals (2011, methodology): “melanogaster nuclei in response to the morphogen Bicoid (Figures 5A and 5B), which is asymmetrically deposited by the mother to the anterior pole of the egg (Gregor et al., 2007).”
Morphogen gradients: from generation to interpretation. (2011, methodology): “Several studies suggest that the Bicoid gradient is very reproducible from embryo to embryo (∼2–10% variability of embryo length) (Gregor et al. 2007a, He et al. 2008, Manu et al. 2009), and artificial cis-regulatory elements that contain only Bicoid binding sites drive expression in remarkably…”
Biomolecular computing systems: principles, progress and potential (2012, background): “However, single-cell measurements of developmental switches showed a tighter response function with high cell-to-cell reproducibility 126 , emphasizing the need to learn lessons from nature in circuit design.”