A 1.9 A crystal structure of the HDV ribozyme precleavage suggests both Lewis acid and general acid mechanisms contribute to phosphodiester cleavage.
By Jui-Hui Chen, R. Yajima, D. Chadalavada, E. Chase, P. Bevilacqua, B. Golden. 2010
117 citations recorded by the source corpus.
Subfields: Hepatology, Infectious Diseases, Molecular Biology
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- B. Masquida
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- Anna Ilaria Przytula-Mally
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- Jun Li
Citations in the corpus
- Anticodon-like loop-mediated dimerization in the crystal structures of HDV-like CPEB3 ribozymes (2023, background): “The HDV ribozyme catalytic core is flanked by the cis G1•U37 and the trans G25oU20 wobble pairs (HDV numbering, Figure 1A), which are crucial for ribozyme activity since their mutations significantly reduce cleavage rate.”