Catalysis for Fluorination and Trifluoromethylation
By T. Furuya, Adam S. Kamlet, T. Ritter. Nature, 2011
1,744 citations recorded by the source corpus.
Recent advances in catalysis have made the incorporation of fluorine into complex organic molecules easier than ever before, but selective, general and practical fluorination reactions remain sought after. Fluorination of molecules often imparts desirable properties, such as metabolic and thermal stability, and fluorinated molecules are therefore frequently used as pharmaceuticals or materials. But the formation of carbon−fluorine bonds in complex molecules is a significant challenge. Here we discuss reactions to make organofluorides that have emerged within the past few years and which exemplify how to overcome some of the intricate challenges associated with fluorination.
Subfields: Inorganic Chemistry, Pharmaceutical Science
View Paper: https://www.semanticscholar.org/paper/84f8dcd934fbf44323e49f48d6aff96e93b635e5
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In Inorganic Chemistry
In Pharmaceutical Science
Citations in the corpus
- Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis (2011, background): “Recently, however, copper and palladium complexes have been successfully shown to enable this transformation in a catalytic fashio”