Microglial phagocytosis of live neurons

By Guy C. Brown, J. Neher. Nature Reviews Neuroscience, 2014

823 citations recorded by the source corpus.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/8497dab35bfd4ce65d2e328bf08085c84a0ee20d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Chao Gao
2. Shengdi Chen
3. Yuyan Tan
4. Jingwen Jiang
5. Morgan Sheng

In Neurology

1. Chao Gao
2. Shengdi Chen
3. Yuyan Tan
4. Jingwen Jiang
5. Oliver D. Howes

Citations in the corpus

• Neuronal Cell Death. (2018, neutral): “The engulfment phase of phagocytosis may depend on activation of P2Y6 receptors on phagocytes by its ligand UDP coming from the engulfed cell (77).”
• The biphasic function of microglia in ischemic stroke (2017, neutral): “Microglia play a beneficial role for tissue remodeling and regeneration after ischemic stroke via clearing dead or dying neurons (Brown and Neher, 2014; Neumann et al., 2009).”
• Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications (2021, background): “The essential characteristic differentiating phagoptosis from other cell death pathways is that cell death can be prevented by the inhibition of phagocytosis.(311) Recognition, engulfment, and digestion are the three main steps in phagoptosis.”
• Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness (2016, background): “Microglia monitor the functional state of synapses, influence neuroplastic changes by remodelling extracellular spaces and eliminate synaptic elements by phagocytosis (Brown and Neher 2014; Kettenmann et al. 2013; Schafer and Stevens 2010).”
• Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023, background): “392 Neuroin fl ammation: In parallel with the detection of microglial activation in the brains of PSP patients, upregulation of the expression levels of pro-in fl ammatory factors was also detected in the substantia nigra, such as IL-1 β .”
• Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions (2022, background): “However, other studies have also pointed out that overenhanced microglia engulfment exacerbates cerebral ischemiainduced brain injuries.(321,322) Hence, microglial phagocytosis may play both beneficial or detrimental roles in ischemic stroke.”
• Microglia in Alzheimer’s disease (2018, background): “The latter study suggested that TREM2 may enable the phagocytosis by microglia of stressed but viable neurons, a process termed phagoptosis (Brown and Neher, 2014).”