Regulation of antioxidant enzymes: a significant role for melatonin

By C. Rodríguez, J. Mayo, R. Sainz, I. Antolín, F. Herrera, V. Martín, R. Reiter. Journal of Pineal Research, 2004

2,023 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Molecular Biology, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/848c3fd5a8e72922df3c065975cb56a086aa23bd

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Citations in the corpus

The dark side of light at night: physiological, epidemiological, and ecological consequences (2007, background): “Melatonin is a well-known antioxidant, playing a significant role in antioxidant defense and regulating antioxidant enzyme activity and production (reviewed in [49]).”
Melatonin as Master Regulator in Plant Growth, Development and Stress Alleviator for Sustainable Agricultural Production: Current Status and Future Perspectives (2020, background): “Melatonin (N‐acetyl‐5‐methoxytryptamine), an indoleamine, was first isolated in 1958 from the bovine pineal gland [1] and named according to its role in reversing the darkening effect of the melanocyte‐stimulating hormone [2].”
Melatonin: a well‐documented antioxidant with conditional pro‐oxidant actions (2014, background): “The melatonin-mediated changes in antioxidant enzyme gene expression are consistent with melatonin’s ability to upregulate the activities of these enzymes [10, 11, 53].”
Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants (2015, background): “This natural antioxidant functions either directly (independent of receptors to scavenge free radicals) or indirectly by regulating the expression and, therefore, activity of antioxidant enzymes including SOD, glutathione peroxidase, and glutathione reductase, as well as stimulates synthesis of glut”
Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies (2017, background): “Actually, there are many controversial and conflicting reports in comparing the antioxidant capacities of SOD and GPX in IBD with their respective controls due to diverse experimental methods and conditions: therefore, additional researches are necessary.”
Melatonin membrane receptors in peripheral tissues: Distribution and functions (2012, positive): “Melatonin, in addition to being a broad-spectrum antioxidant, can also activate cytoprotective enzymes (Rodriguez et al., 2004).”
Recent Developments in Enzymatic Antioxidant Defence Mechanism in Plants with Special Reference to Abiotic Stress (2021, background): “sub-cellular processes such as mitosis [14], cell elongation [15], senescence [16] and cell death [17], and are also involved in a wide range of processes, such as cell differentiation [18], cell growth/division [19], regulation of senescence and sulphate transport [20,21], detoxification of xenobio”
Exogenous melatonin alleviates damage from drought stress in Brassica napus L. (rapeseed) seedlings (2018, background): “showed that MT could directly or indirectly regulate the antioxidant enzyme system and increase enzyme activity in plants (Rodriguez et al. 2004).”
Melatonin in plants (2008, background): “…it also regulates the activity of the antioxidant enzymes such as peroxidases (POX), glutathione reductase (GSSG-R) but also of superoxide dismutase (SOD) and catalase (CAT) (Cardinali and Pévet 1998; Teixeira et al. 2003; Allegra et al. 2003; Rodriguez et al. 2004; Reiter et al. 2007).”
Extrapineal melatonin: sources, regulation, and potential functions (2014, background): “Through this pathway, melatonin can modulate antioxidant gene transcription [44].”