Basic biochemical mechanisms behind the health benefits of polyphenols.
By C. Fraga, M. Galleano, S. Verstraeten, P. Oteiza. Molecular Aspects of Medicine, 2010
701 citations recorded by the source corpus.
Polyphenols and consequently many flavonoids have several beneficial actions on human health. However, the actual molecular interactions of polyphenols with biological systems remain mostly speculative. This review addresses the potential mechanisms of action that have been so far identified, as well as the feasibility that they could occur in vivo. Those mechanisms include: i) non specific actions, based on chemical features common to most polyphenols, e.g. the presence of a phenol group to scavenge free radicals; and ii) specific mechanisms; based on particular structural and conformational characteristics of select polyphenols and the biological target, e.g. proteins, or defined membrane domains. A better knowledge about the nature and biological consequences of polyphenol interactions with cell components will certainly contribute to develop nutritional and pharmacological strategies oriented to prevent the onset and/or the consequences of human disease.
Subfields: Biochemistry, Endocrinology, Diabetes and Metabolism
View Paper: https://www.semanticscholar.org/paper/848b82b557e21f7c367b82a71016d12e855e6fd7
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In Biochemistry
Citations in the corpus
- Polyphenols in Monogastric Nutrition – A Review (2017, background): “Flavonoids are composed of two benzene rings connected through a three-carbon bridge, which form the C6-C3-C6 structural backbone (Jasiński et al., 2009; Fraga et al., 2010).”
- Flavonoids as Anticancer Agents (2020, background): “Flavonoids can directly scavenge ROS, and chelate metal ions [55] due to their ability stabilize the free radicals due to the presence of phenolic hydroxyl groups [56].”
- The Role of Polyphenols in Human Health and Food Systems: A Mini-Review (2018, background): “Current literature suggests that the long-term consumption of diets rich in polyphenols protects against certain cancers, cardiovascular diseases, type 2 diabetes, osteoporosis, pancreatitis, gastrointestinal problems, lung damage, and neurodegenerative diseases (19, 28, 33, 34).”