Genetic clonal diversity predicts progression to esophageal adenocarcinoma
By Carlo C. Maley, P. Galipeau, Jennifer C. Finley, V. Wongsurawat, Xiaohong Li, Carissa A. Sanchez, T. Paulson, Patricia L. Blount, R. Risques, Peter S. Rabinovitch and 1 more. Nature Genetics, 2006
725 citations recorded by the source corpus.
Subfields: Cancer Research, Pathology and Forensic Medicine, Surgery
View Paper: https://www.semanticscholar.org/paper/845abb1d510b1fde8c0920b7192d943d0ab43f97
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
- Nicholas McGranahan
- Charles Swanton
- A. Marusyk
- K. Polyak
- Niko Beerenwinkel
- Moritz Gerstung
- Zena Werb
- R. Weinberg
Citations in the corpus
- Cancer Evolution: Mathematical Models and Computational Inference (2014, background): “Maley et al. (2006) showed that measures of clonal diversity can predict progression of the premalignant Barret’s esophagus to a fullblown adenocarcinoma.”
- CLONAL EVOLUTION IN CANCER (2012, background): “This issue is best addressed by serial sampling, and limited data suggest that parallel clonal expansions occur before subclones begin to dominate in early cancer developmen”
- Evolution and impact of subclonal mutations in chronic lymphocytic leukemia (2013, neutral): “…typically removes the incumbent clones (Jablonski, 2001)— acting like a ‘‘mass extinction’’ event (Jablonski, 2001)—and shifts the evolutionary landscape (Nowak and Sigmund, 2004; Vincent and Gatenby, 2008) in favor of one or more aggressive subclones (Maley et al., 2006; Figure 7D, bottom).”
- ACG Clinical Guideline: Diagnosis and Management of Barrett’s Esophagus (2015, positive): “Abnormalities including DNA content abnormalities, chromosomal abnormalities, gene mutations, methylation changes, and clonal diversity measurements defi ne patients at increased risk for progression to cancer ( 128–132 ).”
- Emergence of Spatial Structure in Cell Groups and the Evolution of Cooperation (2010, background): “Variation among individual cells is a common feature of many cell groups: microbial biofilms are often composed of multiple strains or species [13,14], and cancerous tumors can consist of many different genetic lineages [15,16].”
- Tumor heterogeneity: causes and consequences (2009, methodology): “Studies of clonal heterogeneity may rely on the detection of amplification of specific chromosomal regions by fluorescent in situ hybridization (FISH) [11,26,42,44,47] or immuno-FISH (FISH coupled with immunofluorescence) analysis [12].”
- Biological and therapeutic impact of intratumor heterogeneity in cancer evolution. (2015, background): “Indeed, esophageal adenocarcinomas are characterized by genome doublings and have elevated genetic clonal diversity compared with never-dysplastic Barett’s esophagus (Li et al., 2014; Maley et al., 2006).”