A planning strategy for diversity-oriented synthesis.

By M. Burke, Stefan Schreiber. Angewandte Chemie, 2004

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Privileged Scaffolds for Library Design and Drug Discovery (2010, background): “Additional strategic approaches to achieve diversity include reagentbased differentiation pathways [27 ], substrate-based folding pathways [27 ], and the three-phase build/ couple/pair strategy [28 ], which are discussed in detail in the cited references.”
NATURAL PRODUCTS: A CONTINUING SOURCE OF NOVEL DRUG LEADS (2013, methodology): “The synthesis of natural-product-like libraries is exemplified by the work of the Schreiber group, who combined the simultaneous reaction of maximal combinations of sets of naturalproduct-like core structures (“latent intermediates”) with peripheral groups (“skeletal information elements”) in the sy”
The evolving role of natural products in drug discovery (2005, background): “The diversity-oriented approach seeks to leverage the privileged structural motifs of natural-product scaffolds to synthesize combinatorial libraries capable of binding a wide range of biological target”
Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules. (2010, background): “Small molecular mass chemical entities (so-called small molecules) have always been of interest in chemistry and biology because of their ability to exert powerful effects on the functions of macromolecules that comprise living system”