Interaction of Cardiovascular Risk Factors with Myocardial Ischemia/Reperfusion Injury, Preconditioning, and Postconditioning

By P. Ferdinandy, R. Schulz, G. Baxter. Pharmacological Reviews, 2007

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Anti-apoptosis and cell survival: a review. (2011, background): “cascades such as ERK and Akt, many of which are known to have antiapoptotic properties [53].”
Cell Biology of Ischemia/Reperfusion Injury (2012, background): “Importantly, there is now mounting evidence that many disorders such as diabetes, hyperlipidemia, and aging can affect the development of I/R injury per se, independent of the vascular aspects (Boengler et al., 2009; Ferdinandy et al., 2007).”
Myocardial ischemia-reperfusion injury: a neglected therapeutic target. (2013, positive): “Many experimental MI models fail to represent the clinical setting of an MI in terms of comorbidities (such as age, diabetes, dyslipidemia, and hypertension) and concomitant medication, the presence of which may interfere with the therapeutic cardioprotective intervention (91).”
Reperfusion injury and reactive oxygen species: The evolution of a concept (2015, background): “…α-KDH, α-ketoglutarate dehydrogenase; LTB4, leukonese superoxide dismutase; MPTP, mitochondrial permeability transition pore; mtROS, mitochondrial reactive oxygen xidized); NADH, Nicotinamide adenine dinucleotide (reduced); NADPH, Nicotinamide adenine dinucleotide phosphate; genase;…”